AVAILABLE FORMS:
Capsules: 325mg; 500mg
Gelcaps: 500mg
Oral Liquid: 160mg/5ml; 500mg/15ml
Oral suspension: 80mg/ml; 120mg/5ml; 160mg/15ml
INDICATIONS:
- Mild pain
- Fever
MECHANISM OF ACTION:
It has been assumed that paracetamol acts by reducing production of prostaglandins, which are involved in the pain and fever processes, by inhibiting the cyclooxygenase (COX) enzyme. Thought to produce analgesia by blocking generation of pain impulses, probably by inhibiting prostaglandin synthesis.
ADVERSE REACTION:
Hematologic: hemolytic anemia, neutropenia, leukopenia, pancytopenia
Hepatic: Liver damage, jaundice
Metabolic: hypoglycemia
Skin: rash, urticaria
NURSING CONSIDERATIONS:
- Use cautiously in patients with history of chronic alcohol use.
- Smoking cigarettes may interfere with the effectiveness of acetaminophen.
- It interferes with the results of some medical tests.
- People should check with a physician or pharmacist before combining acetaminophen with any other prescription or nonprescription (over-the-counter) medicine.
- Overdoses of acetaminophen may cause nausea, vomiting, sweating, and exhaustion. Very large overdoses can cause liver damage. In case of an overdose, a person is advised to get immediate medical attention.
- Tell breast feeding mothers that acetaminophen appears in breast milk in low levels.
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