Co-Trimoxazole

INDICATIONS & DOSAGES

• Shigellosis
• Otitis media
• Chronic bronchitis, upper respiratory tract infections
• Traveler's diarrhea
• P.carinii pneumonia

ACTION

Sulfamethoxazole inhibits formation of dihydrofolic acid from PABA; trimethprim inhibits dihydrofolate reductase formation. Both decrease bacterial folic acid synthesis; bactericidal.

ADVERSE REACTIONS

CNS: headache, mental depression, aseptic meningitis, tinnitus, apathy, seizures, hallucinations, ataxia, nervousness, fatigue, vertigo, insomnia.

CV:thrombophlebitis

GI:nausea, vomiting, diarrhea, abdominal pain

GU:crystalluria, hematuria, interstitial nephritis.

Hematologic:agranulocytosis, aplasticanemia, megaloblastic anemia, thrombocytopenia, leukopenia, hemolytic anemia.

Hepatic:jaundice, hepatic necrosis.

Musculoskeletal:arthralgia, myalgia, muscle weakness.

Respiratory:pulmonary infiltrates

Skin:erithema multiforme, Stevens-Johnson syndrome, generalized skin eruption,

epidermal necrolysis, exfoliative dermatitis, photosensitivity, urticaria, pruritus.